IL-21 human rec.
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Product information "IL-21 human rec."
IL-21 is produced by CD4+ T-cells in response to antigenic stimulation. Its action enhances antigen-specific responses of immune cells.
The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells, stimulation (in conjunction) with IL-4 of IgG production, and induction of apoptotic effects in naive B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK-cells.
IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.
IL-21 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 132 amino acids and having a total molecular mass of 15.4kDa. The IL-21 is purified by proprietary chromatographic techniques.
Synonyms: IL21, Za11
| Liquid / Powder: | Powder |
|---|---|
| Product Category: | Cytokines and Growth Factors |
| Size: | 10 µg |
| Sterile: | Yes |
| Storage: | See Datasheet |