Adiponectin Trimeric Form human rec.

Adiponectin is a hormone exclusively expressed in adipose tissue. Many studies demonstrate that adiponectin has direct anti-diabetic, anti-atherogenic and anti-inflammatory functions. APM-1 can increase insulin sensitivity of skeletal muscle, attenuate hepatic lipogenesis and gluconeogenesis, regulate NO production in endothelial cells, inhibit proliferation of smooth muscle cells and prevent lipid accumulation of macrophage cells. In the circulation, adiponectin is present as three different oligomeric complexes, including the high molecular weight (HMW), the middle molecular weight (MMW, also called hexamer) and low molecular weight (LMW, also called trimer) forms. Different oligomeric complex of adiponectin activates different signaling pathways and exerts distinct functions. Adiponectin (Acrp30 Tri) human trimeric form was expressed in HEK293 cells. The Cysteine 39 was replaced with Alanine (C39A). Adiponectin C39A can only form a trimer, but not a hexamer or a HMW form.

Synonyms: Acrp30, AdipoQ, GBP-28, APM-1, ACDC