IL-15 human rec.
Product information "IL-15 human rec."
Interleukin 15 is a protein that regulates T and natural killer cell activation and proliferation. As a pleiotropic cytokine, it plays an important role in innate and adaptive immunity. Cytokines and interleukines share many biological activities.
IL-15 is constitutively expressed by a large number of tissues and cell types, including monocytes, macrophages, dendritic cells (DC), keratinocytes, fibroblasts and nerve cells.
They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6.
Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported.
Interleukin-15 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 114 amino acids (and an N-terminal Methionine) and having a molecular mass of 12.8kDa. The IL-15 is purified by proprietary chromatographic techniques.
Synonyms: Interleukin 15, IL-15, MGC9721
| Liquid / Powder: | Powder |
|---|---|
| Product Category: | Cytokines and Growth Factors |
| Size: | 10 µg |
| Sterile: | Yes |
| Storage: | See Datasheet |